Splenda - Sucralose - Aspartame:
Splenda, also known as sucralose, is an artificial sweetener which is a chlorinated sucrose derivative. Facts about this artificial chemical follows:
Pre-approval research showed that sucralose caused shrunken thymus glands (up to 40% shrinkage) and enlarged liver and kidneys. The manufacturer put forth two arguments in an attempt to claim that sucralose is not toxic:
- The dose of sucralose in the experiments was high. However, for chemicals that do not have generations of safe use, the dosage tested must be adjusted for variations in potential toxicity within the human population and between humans and rodents. In order to this, toxicologists estimate a variation of effects in the human population of 10 times. In other words, one person may not have effects until a dose of 10 mg per kg of body weight (10 mg/kg) is reached, while another person may have chronic toxicity effects at 1 mg per kg of body weight (1 mg/kg). In addition, it is well known that many chemicals are much more toxic in humans than in rodents (or even monkeys). For example, the chemicals that the sweetener aspartame breaks down into vary from 5 to 50 times more toxic in humans than in rodents. Therefore, toxicologists estimate a further 10 times the dose for differences between human and rodent toxicity for a total of 100 times (10 * 10).
- In order to estimate a potential safe dose in humans, one must divide the lowest dose in given to rodents that was seen to have any negative effects on their thymus glands, liver or kidneys by 100. That dose is then known as the maximum Tolerable Daily Intake (TDI) for lifetime use. Keep in mind that the TDI is just an estimate. Some chemicals are much more than 10 times more toxic in humans than in rodents (or will cause cancer in humans in low-dose, long-term exposure and do not cause cancer in rodents at all). A person ingesting the TDI for some chemical may find that it causes cancer or immune system or neurological problems after many years or decades of use. So, if the manufacturer claims that the dose was equivalent to 50 diet sodas, then the TDI would be one half (1/2) of a diet soda, and even that dose may or may not be safe.
- The manufacturer claimed that the sucralose was unpleasant for the rodents to eat in large doses. They said that starvation caused the shruken thymus glands. From the New Scientist (23 Nov 1991, pg 13):
- Toxicologist Judith Bellin reviewed studies on rats starved under experimental conditions, and concluded that their growth rate could be reduced by as much as a third without the thymus losing a significant amount of weight (less than 7 percent). The changes were much more marked in rats fed on sucralose. While the animals' growth rate was reduced by between 7 and 20 percent, their thymuses shrank by as much as 40 percent.
Other adverse effects reported in pre-approval research included:
- Shrunken thymus glands (up to 40% shrinkage)
- Enlarged liver and kidneys
- Atrophy of lymph follicles in the spleen and thymus
- Increased cecal weight
- Reduced growth rate
- Decreased red blood cell count
- Hyperplasia of the pelvis
- Extension of the pregnancy period
- Aborted pregnancy
- Decreased fetal body weights and placental weights
- Diarrhea
Sweeteners To Use |
Sweeteners To Avoid |
| Stevia (Safe For Everyone) | Aspartame (NutraSweet, Equal, Canderel) |
| Other Low Carb Sweeteners | Neotame |
| Evaporated Cane Juice | Sucralose (Splenda, Altern) |
| Fruit Juice (No Sugar Added) | Acesulfame-K (Sunette, Sweet & Safe, Sweet One) |
| Rice Syrup | Cyclamates |
| Honey | Saccharin |
| Licorice Root (small amounts) | Refined Sugar |
| Fructooligosaccharides (FOS) | High Fructose Sweeteners |
| Amasake | Other Aspartame Sweetners (Spoonful, Equal Measure) |
| Vegetable Glycerin | Other Aspartame Sweetners (Ameno Sweet, Benivia) |
| Sugar Alcohols (xylitol, sorbitol) ^ | Other Aspartame Sweetners (Nutra Taste) |
| Maple Syrup (Without Added Sugar) | Other Aspartame Sweetners (In Some Diet Foods) |
| Barley Malt | Other Aspartame Sweetners (In Some Diet Beverages) |
| ^ Use In Small Amounts & Avoid If You Have Bowel Disease |
Splenda Information: Dr. Mercola 12/3/2000 - Dangers
Splenda Information: Dr. Mercola 12/3/2000 - Testimonials
Splenda Information: Dr. Mercola 8/23/2003 - Not A "Healthy" Sweetener
Splenda Information: Dr. Mercola 11/8/2003 - One Man's Personal Story
Splenda Information: Dr. Mercola 4/2/2007 - They Aren't Telling You
Splenda Information: Dr. Mercola 5/14/2007 - France Bans Splenda Ads
Splenda Information: Dr. Mercola 12/25/2007 - Lawsuit Against Splenda Moves Forward
Splenda Information: Dr. Mercola 2/10/2009 - Shocking Information About Potential Harmful Effects
Splenda Information: Dr. Mercola 6/20/2011 - DOUBLES Your Risk of Gaining Pounds
Splenda Information: Dr. Mercola 10/8/2011 - The 4 Best, And 3 Worst, Sweeteners To Have In Your Kitchen
Splenda Information: Sugar Association Website - Truth About Splenda
Splenda Information: Natural News 10/20/2008 - Duke University Study Links Splenda To Weight Gain
Splenda Information: Natural News 10/9/2012 - Stop Using Splenda
