Bio-Identical Hormones:

When getting hormones from a pharmacy, be aware that there are natural and synthetic hormones. Synthetic hormones are only part of the molecular structure, of natural hormones and will not improve hormone deficiency. In fact they will worsen the condition for which you took them, in the first place.

My recommendation is to take bio-identical hormones of the sublingual type. I have found the absorption to be about 10 times better with sublingual hormones, than with transdermal hormones. The sublingual form I use is called a Troche (pronounced trokey).

Bio-identical hormones, consist of the exact molecular structure of the hormones that are made in your body. They are made from plant sources and are exactly the same, as nature made them in us.

When writing prescriptions, doctors should keep in mind that bio-identical hormones will have no negative effect on the body, if they are prescribed in quantities that are consistent, with levels needed for optimal health. On the other hand, synthetic hormones made by major pharmaceutical companies, are mostly prescribed by allopathic doctors and can have major negative effects on every part of the body.

30 Points Of Interest For Men With Prostate Cancer

Transcription by Jerry Sloane from articles published by Dr. John R. Lee M.D. As a noted expert on hormones, Dr. Lee was primarily known for his work, with women's hormones. Listed below are some of his statements (which have been shortened) for this publication and are attributed to Dr. Lee.

1. All disease comes from metabolic imbalance. When the underlying metabolic imbalance is corrected, the disease goes away. If you fail to keep up the correction, for the underlying metabolic imbalance, the disease will come back.

2. Cancer is caused by an underlying metabolic imbalance, that turn normal cells into cancer cells.

3. The same things that cause breast and cervical cancer in women, causes prostate cancer in men and that is metabolic acidosis estrogen dominance.

4. Testosterone does not cause prostate cancer. If it did men would get prostate cancer at an early age, when testosterone levels are at their highest point.

5. As men age, the testosterone level falls and estrogen dominance is the result.

6. When the standard oblation drugs are given to men, to fight prostate cancer, the short term results come from the suppression of all hormones and not just from testosterone. That means there is no estrogen dominance. Whatever benefit is realized might be due to estrogen inhibition, rather than testosterone inhibition.

7. Conventional medicine derives its information from the notion that started in 1941, when Dr Huggins showed that castration appeared to increase survival rates, in men with prostate cancer. What has followed since then is a trail of testosterone lowering treatments, based on Dr. Huggins observation. Surgical castration, chemical castration, a temporary sojourn into estrogen therapy and testosterone receptor inhibitors, all to little or no avail. The evidence that testosterone reduction reduces the mortality rates in men with prostate cancer, is still missing.

8. Dr. Huggins did not consider that castration reduces not only the testosterone, but all sex hormones.

9. From Dr. Huggins own data, it is equally valid to argue that estrogen dominance may have been responsible, for the increased survival rates he observed, among castrated men.

10. When testosterone is blocked, men quickly develop depression, diarrhea, dementia and eventually they die right on time. All humans need some testosterone.

11. Despite this sad record of failure, conventional physicians still believe that testosterone causes prostate cancer. The usual reason is their reliance on PSA. The belief is widespread that a rising PSA level is a sign of increased cancer risk. The fact is that PSA is a normal antigen, made by normal prostate cells, that creates an anti-ontogenesis effect, in response to cellular crowding, as happens when normal prostate cells are crowded by neighboring prostate cancer cells.

12. Therefore, PSA is a defense mechanism of normal prostate cells, against prostate cancer cells.

13. An elevated PSA does not make cancer worse. A worsening of one's cancer condition, may stimulate higher PSA levels. The goal is to find a treatment that increases one's cancer defenses and selectively impair's cancer cell growth. If successful, then we would eventually see a decline in PSA levels.

14. The highest testosterone levels in males are made during one's late teens, at a time when no one gets prostate cancer. Conversely, men's prostate cancer risk rises, when testosterone and progesterone have fallen and estradiol has risen.

15. Testosterone is a direct antagonist to estradiol. Women develop full breasts because their estradiol effect is stronger than their testosterone effect. Men make estradiol, but throughout most of the young and middle adult life, they make more testosterone, sufficient to block female breast development. Testosterone is the major masculinizing hormone and estradiol is the major feminizing hormone. The ratio of testosterone to estradiol (T/E2), is the major operant factor.

16. The relationship of estradiol to progesterone, is that they are designed to work together, by balancing their mutually opposing properties, to produce the optimal hormone benefit to both men and women. Unopposed estradiol is lethal. Progesterone is necessary to prevent potent undesirable side effects, of unopposed estradiol. Thus, the ratio of progesterone to estradiol( P/E2 ) is very important. The fact is that unopposed estradiol is carcinogenic. Estradiol is a very potent hormone, whereas progesterone is a very mild hormone. Optimal protection against estradiol induced cancer, occurs when the saliva progesterone level is about 200 to 300 times, that of the saliva estradiol level.

17. Thus men are protected against estradiol induced prostate cancer, as long as their testosterone and progesterone sufficiently dominate their estradiol level. They lose this protection, when their E2 eventually rises sufficiently and their testosterone and progesterone levels fall sufficiently. This is a gradual process in men, starting in their forties.

18. The male prostate gland in many ways, is equivalent to the uterus. They both originated from the same embryonic tissue, at about day 20 of embryonic life. It should not be surprising, that prostate and endrometrial tissue respond similarly to genetic codes, that both carry. Cancer of the endometrium has only one known cause and that is estrogen dominance. The DNA of breast tissue, endrometrial tissue and prostate tissue all respond the same way.

19. It is known, that the activity of gene BCL-2, increases endrometrial cancer cell proliferation, whereas activity of gene P53 inhibits the effects of gene BCL-2 and reduces proliferation, of endrometrial cancer cells. The important point here is that estradiol stimulates BCL-2 activity, whereas progesterone and or testosterone stimulates gene P53 activity. It is known that the same findings apply to prostate tissue.

20. The key to preventing prostate cancer, is to avoid estrogen dominance. In addition to the mistaken notion that testosterone causes prostate cancer, conventional medicine persists in using serum testing, to measure blood levels of sex hormones. Serum measurements do not distinguish between protein bound and free hormones. Serum measurements miss all the free hormones, being carried by red blood cells. when blood flows through tissues, such as saliva glands, only the free hormone filters into tissues. thus, measuring sex hormones levels found in saliva, is far more reliable and relevant, than serum tests.

21. Hormones should be given only to people that need them. Conventional medicine has been giving potent sex hormones to women, without proving that they are deficient in them. Doctors would not give insulin to anyone, without proving that they needed it. The same should be true for any hormone.

22. You should get only bio-identical natural human hormones, rather than synthetic hormones. Synthetic hormones differ from natural hormones and all have side effects, not found in natural hormones.

23. General dosages for men deficient in progesterone and or testosterone are as follows:

Transdermal Progesterone 6 - 8 mg. and Transdermal Testosterone 1.5 - 2 mg. per day

Sublingual Progesterone .6 - .8 mg. and Sublingual Testosterone .15 - .2 mg. per day

24. Dosages vary depending on absorption and excretion kinetics. Saliva levels should be re-tested every 4 to 6 months of transdermal or sub lingual use. When testing for the effect of the applied hormone, it is wise to standardize the time between dosing and saliva collection. Saliva collection should be done 12 hours after the application of the hormone.

25. For progesterone, the goal is to raise the saliva progesterone level to 200 - 300 times greater than the saliva estradiol level.

26. For testosterone, the goal is to raise the saliva testosterone level to 200 - 300 times greater than the saliva estradiol level.

27. It is common for older men to have a saliva testosterone level of 20 - 24 PG/ML., while at the same time their serum level is over 200. With the addition of just 1 - 2 MG. of transdermal or sub-lingual testosterone, their saliva level rises 5 - 10 fold.

28. When women undergo removal of their ovaries they lose the major production of their testosterone. This produces depression, lack of libido, fatigue, et cetera. When given transdermal or sub lingual testosterone, they return back to good health. The usual effective dose is just 0.25 - 0.50 MG. per day. This dose is sufficient to raise testosterone levels 5 fold.

29. The key factor is to prevent estrogen dominance. The most relevant test for hormone balance is the saliva hormone assay. If the test reveals estrogen dominance and or progesterone and testosterone deficiency, the estrogen dominance can be corrected, by proper supplementation with progesterone and testosterone.

30. Correction of diet, life style and environmental factors, can be used for prevention as well as for the treatment of prostate cancer.

SEX HORMONE BINDING GLOBULIN (SHBG)

SHBG as measured in blood (the same as other sex hormones) are mostly protein bound and can do no work in the body. They are in effect used hormones.

Whether measured in saliva or blood the following would be true.

SHBG is Decreased by the Herb Stinging Nettles
SHBG is Decreased by the Herb Avinacosides
SHBG is Decreased by the Herb Carao
SHBG is Decreased by the Herb Muira Puama
SHBG is Decreased by the Herb Tongkat Ali
SHBG is Decreased by the Herb Catuaba
SHBG is Decreased by high levels of Blood Sugar
SHBG is Decreased by high levels of IGF-1
SHBG is Decreased by high levels of Testosterone
SHBG is Increased by high levels of Estradiol

AROMATASE INHIBITORS

Aromatase is an enzyme required for the conversion of androgens to estrogens. Aromatase inhibitors thus decrease the concentrations of estrogens in the body and are effective against tumors that depend on estrogen for growth.

Aromatase, an enzyme found in the liver, in responsible for the conversion of the androgens ANDROSTENEDIONE and TESTOSTERONE into the estrogens ESTRONE and ESTRADIOL. By inhibiting aromatase the body produces less estrogen and maintains a higher testosterone state.

In men, aromatase activity increases with age, converting what little testosterone is left into estrogen. It is perhaps this event that is most responsible for the many symptoms of male menopause, and possibly even enlarged prostates and prostate cancer.

The long held theory of prostate cancer, that testosterone is bad stuff, and even worse when its converted to dihydrotestosterone, is gradually falling into disfavor.

A more prevalent current opinion is that prostate cancer has more to do with estrogen than with dihydrotestosterone. It appears that many men, as they get older, convert too much testosterone to estrogen and that this excessive estrogen is the cause of prostate enlargement or prostate cancer.

When supplementing with Testosterone, Aromatase Inhibitors will prevent some Testosterone from converting to Estradiol. The following herbs and nutrients will help prevent this conversion.

Progesterone (Bio-Identical)
Apigenin Found in most species of Chamomile, the flavone apigenin is also a safe and effective aromatase inhibitor, with an inhibitory effectiveness about equal to chrysin.
Chrysin Found in the herb Passiflora incarnata, the flavone chrysin is a potent natural aromatase inhibitor. In a study published 1993 chrysin and 10 other flavonoids were compared to an aromatase-inhibiting drug (aminoglutethimide). Chrysin was the most potent aromatase-inhibitor, and was shown to be similar in potency and effectiveness to the aromatase-inhibiting drug. The scientists conducting the study concluded by stating that the aromatase-inhibiting effects of certain flavonoids may contribute to the cancer preventive effects of plant-based diets.
Diadzein (from soy isoflavones)
Dim (Di-Indoly Methane). These compounds, found in cruciferous vegetables like cabbage, brussels sprouts, cauliflower, collards and broccoli, help to transform dangerous estrogen into more benign forms, as recognized by the National Cancer Institute.
Genistein (from soy isoflavones)
Glycitein (from soy isoflavones)
I3C (the precursor of Dim, only one tenth as strong), These compounds, found in cruciferous vegetables like cabbage, brussels sprouts, cauliflower, collards and broccoli, help to transform dangerous estrogen into more benign forms, as recognized by the National Cancer Institute. They have also been shown to stop the growth of breast-cancer cells by inhibiting the action of a specific enzyme.
Magnesium is an essential element and is the fourth most abundant in nature.
Tribulis Terrestries is an herb that stimulates the production of Luetinizing Hormone (LH). An increase in the amount of LH in the body stimulates the testicles to produce more testosterone.
Zinc deficient diets increase the aromatization of testosterone and the formation of estradiol.
Possibly Saw Palmetto
Possibly Resveritrol

5 ALPHA REDUCTASE INHIBITORS

High levels of DHT (dihydrotestosterone) is thought to cause BPH (benign prostatic hyperplasia) in men as well as loss of hair. The loss of hair is unrelated to BPH, as the genetic mechanism is different. The following herbs may be used to prevent 5 Alpha Reductase from causing excess Testosterone from converting to DHT

Some of the following also have a secondary effect, which is to prevent hair loss in those that are genetically susceptible.

Beta Sitosterol contains a mixture of phytersterols. Phytersterols (sterols) have anti-androgenic properties. This is the substance that is able to block DHT.
Black Cohash Extract test results indicate that the extract BNO 1055 contains one or more potent 5alpha-reductase inhibitors.
Emu Oil contains a high level of linolenic acid. Linolenic acid is a potent 5 alpha reductase inhibitor and may be useful in the treatment of disorders related to the hormone DHT.
Green Tea is an extremely powerful anti-oxidant. It also reduces DHT and cholesterol.
L-Lysine While L-Lysine is NOT a DHT blocker. It may make dht blockers more effective.
Nettle Root German research suggests that active ingredients in the nettle root may reduce prostate swelling.
Pumpkin Seed Oil breaks down DHT via the liver.
Pygeum inhibits the production of DHT. Pygeum also has ingredients that reduce prolacting levels and block the accumulation of cholesterol in the prostate.
Salmon contains Astaxanthin and may block 5 alpha reductase
Saw Palmetto Firstly it lowers levels of DHT in the body by blocking 5 alpha-reductase. Secondly Saw Palmetto block receptor sites on cell membranes required for cells to absorb DHT.
Small Flowered Willow Herb has been used for years in Europe for the treatment of Prostate Disease which includes Benign Prostatic Hyperplasia, Prostatitis (usually a bacterial infection of the prostate) and Prostate Cancer.
Soy Isoflavones containing Diadzein - Genistein - Glycitein

HORMONE SALIVA TEST

This Is A SALIVA TEST, That Can Be Done At Home And Sent To The Test Lab.
Tests For: Estrone, Estradiol, Progesterone, Testosterone, DHT And DHEA
Women Should Also Test Estriol.

Aeron Life Cycles (San Leandro, Ca), www.aeron.com, 800-631-7900
Will Bill Medicare And Some Other Insurance Companies.

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